Vesicle fusion with Golgi apparatus

Across TCGA cell cohorts, RNA activity of the Vesicle fusion with Golgi apparatus pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF8, TFIP11, and KLF11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAF8 grouped by Vesicle fusion with Golgi apparatus-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TAF8 →	-0.287	-1.488	.007	<.001	3	4
LUNG_NSCLC_LUSC	TFIP11 →	-0.468	-1.507	.004	.001	3	4
URINARY_TRACT	KLF11 →	-0.130	-1.879	<.001	<.001	3	3
SOFT_TISSUE	DIMT1 →	-0.283	-1.681	.001	<.001	3	3
BLOOD_Myeloma	DICER1 →	+0.342	+1.386	.002	<.001	3	3
BLOOD_Lymphoma	CPS1 →	-0.280	-1.592	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF8 by Vesicle fusion with Golgi apparatus activity — BONE

Explore this box plot interactively →