Clathrin coat assembly

Across TCGA patient cohorts, RNA activity of the Clathrin coat assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNAJC7, RRP9, and RPL5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clathrin coat assembly activity versus DNAJC7 in LSCC (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DNAJC7 →	-0.243	-0.051	.001	.005	3	7
GBM	RRP9 →	-0.278	-0.071	.001	<.001	3	6
BRCA	RPL5 →	-0.277	-0.076	<.001	<.001	3	6
BRCA	SUSD2 →	+0.595	+0.067	<.001	<.001	3	6
BRCA	AK1 →	+0.500	+0.079	<.001	<.001	3	6
GBM	HAAO →	+0.529	+0.097	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048268 vs DNAJC7 — LSCC

Explore this scatter interactively →