Negative regulation of receptor-mediated endocytosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of receptor-mediated endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CERCAM, LINC01126, and PCOLCE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor-mediated endocytosis activity versus CERCAM in GBM (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CERCAM →	+0.614	+0.145	.007	.008	3	5
UCEC	LINC01126 →	-0.545	-0.190	.005	.002	3	5
LSCC	PCOLCE →	+0.892	+0.312	<.001	.003	3	4
OV	COL1A1 →	+2.165	+0.209	<.001	.001	3	4
LSCC	SPARC →	+0.603	+0.176	<.001	.002	3	4
OV	RASGRF2 →	+0.597	+0.157	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048261 vs CERCAM — GBM

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