Regulation of receptor-mediated endocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of receptor-mediated endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFAF4, ATP5F1B, and MYBBP1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor-mediated endocytosis activity versus NDUFAF4 in SOFT_TISSUE (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NDUFAF4 →	-0.763	-0.294	<.001	.007	2	7
PANCREAS	ATP5F1B →	-1.021	-0.252	.002	.001	3	6
LARGE_INTESTINE	MYBBP1A →	-0.525	-0.176	.004	.001	3	6
BONE	SHMT2 →	-1.081	-0.205	.003	.008	2	7
SOFT_TISSUE	PPM1G →	-0.795	-0.338	<.001	.001	2	6
PANCREAS	ZNF428 →	-1.195	-0.319	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048259 vs NDUFAF4 — SOFT_TISSUE

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