Epinephrine transport

Across TCGA patient cohorts, RNA activity of the Epinephrine transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2_T755, ADRA2A_S346, and SH3BP4_S246, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epinephrine transport activity versus SYNPO2_T755 in COAD (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SYNPO2_T755 →	+0.540	+0.039	.001	.006	3	5
COAD	ADRA2A_S346 →	+0.534	+0.050	<.001	<.001	3	5
GBM	SH3BP4_S246 →	+0.257	+0.096	.008	<.001	3	4
COAD	CNN1 →	+0.892	+0.050	<.001	.003	3	4
COAD	EML1 →	+0.396	+0.044	.001	.002	3	4
COAD	MAP1B_T1949 →	+0.474	+0.048	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048241 vs SYNPO2_T755 — COAD

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