Sperm capacitation

Across TCGA cell cohorts, RNA activity of the Sperm capacitation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KBTBD8, SPIRE1, and PGLYRP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm capacitation activity versus KBTBD8 in BLOOD_Leukemia (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KBTBD8 →	-1.039	-1.931	.004	.002	3	3
LUNG_SCLC	SPIRE1 →	+1.123	+1.580	.008	<.001	3	2
LUNG_SCLC	PGLYRP1 →	-0.483	-1.491	.001	<.001	3	2
PANCREAS	RAB5IF →	-1.233	-1.786	.003	<.001	2	3
STOMACH	STUB1 →	-1.425	-1.751	.005	<.001	3	2
OVARY	RP2 →	-1.406	-2.166	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048240 vs KBTBD8 — BLOOD_Leukemia

Explore this scatter interactively →