Plasma membrane to endosome transport

Across TCGA patient cohorts, RNA activity of the Plasma membrane to endosome transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PBRM1, RRP9, and USP6NL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane to endosome transport activity versus PBRM1 in LSCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PBRM1 →	+0.223	+0.060	.008	<.001	3	5
PDAC	RRP9 →	-0.211	-0.058	.001	<.001	3	5
COAD	USP6NL →	+0.470	+0.038	<.001	<.001	3	5
PDAC	SYNPO2_S638 →	+0.315	+0.030	.008	.003	3	5
GBM	SBSPON →	+0.790	+0.036	<.001	.001	3	4
GBM	SIRT6 →	-0.160	-0.028	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048227 vs PBRM1 — LSCC

Explore this scatter interactively →