"Vesicle targeting, rough ER to cis-Golgi"

Across TCGA patient cohorts, RNA activity of the "Vesicle targeting, rough ER to cis-Golgi" pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A9_T113, DHRS11_S197, and TMCC1_S134, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Vesicle targeting, rough ER to cis-Golgi" activity versus S100A9_T113 in BRCA (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	S100A9_T113 →	-0.828	-0.020	.007	<.001	3	5
PDAC	DHRS11_S197 →	-0.796	-0.031	<.001	.003	3	5
LUAD	TMCC1_S134 →	+0.360	+0.027	<.001	<.001	3	4
LSCC	MYO9B_S1122 →	-0.384	-0.033	.003	<.001	3	4
HNSC	PDLIM5_T417 →	-0.587	-0.068	.003	<.001	3	4
LUAD	FGD6_S605 →	+0.575	+0.036	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048207 vs S100A9_T113 — BRCA

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