"Vesicle targeting, rough ER to cis-Golgi"

Across TCGA pan-cancer cohorts, RNA activity of the "Vesicle targeting, rough ER to cis-Golgi" pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 27 member genes.

The strongest signal is observed in kidney chromophobe (KICH), where higher "Vesicle targeting, rough ER to cis-Golgi" pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and LIHC, show the opposite pattern, with higher activity associated with better survival.

KICH, KIRC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	0.292	1.000	<.001	77	view →
KIRC	DFS	Median	III,IV	0.352	0.559	.002	70	view →
ACC	DFS	Median	II,III,IV	0.151	0.575	<.001	62	view →
UVM	DFS	Median	II,III,IV	0.355	0.698	.012	30	view →
BRCA	OS	Tertile	All	0.975	0.951	.008	24	view →
LIHC	OS	Tertile	III,IV	0.811	0.409	.004	11	view →
CHOL	DFS	Median	All	0.634	0.214	.013	9	view →
READ	DFS	Median	II,III,IV	0.851	0.578	.039	9	view →
LGG	DFS	Median	All	0.628	0.809	.009	8	view →
SKCM	OS	Quartile	III,IV	0.546	0.307	.007	6	view →
STAD	OS	Median	IV	0.682	0.249	.028	6	view →
BLCA	OS	Median	All	0.519	0.343	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0048207–KICH (DFS)

Open the KICH breakdown →