"Vesicle targeting, rough ER to cis-Golgi"

Across TCGA patient cohorts, RNA activity of the "Vesicle targeting, rough ER to cis-Golgi" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMCC2, YEATS2, and ATL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Vesicle targeting, rough ER to cis-Golgi" activity versus TMCC2 in BRCA (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMCC2 →	-0.680	-0.178	.001	.002	2	5
BRCA	YEATS2 →	-0.366	-0.130	.001	.008	3	4
LUAD	ATL1 →	-0.286	-0.119	.008	<.001	3	4
LUAD	DNAJC27-AS1 →	-0.292	-0.107	.001	.007	3	4
UCEC	NANS →	+0.830	+0.190	.003	.003	3	4
LSCC	BOLA3-AS1 →	-0.608	-0.166	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048207 vs TMCC2 — BRCA

Explore this scatter interactively →