"Vesicle targeting, rough ER to cis-Golgi"

Across TCGA cell cohorts, RNA activity of the "Vesicle targeting, rough ER to cis-Golgi" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCAT, MTR, and SAMD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GCAT grouped by "Vesicle targeting, rough ER to cis-Golgi"-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GCAT →	+1.300	+0.348	.002	.003	3	4
CNS	MTR →	-0.488	-0.264	.001	<.001	3	4
CNS	SAMD1 →	-0.613	-0.253	.007	.009	3	4
LIVER	CNN1 →	-4.220	-0.380	.002	.009	3	4
LIVER	CIZ1 →	-0.743	-0.404	<.001	<.001	3	4
OVARY	CLIC5 →	+2.510	+0.249	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GCAT by "Vesicle targeting, rough ER to cis-Golgi" activity — BLOOD_Leukemia

Explore this box plot interactively →