Regulation of short-term neuronal synaptic plasticity

Across TCGA patient cohorts, RNA activity of the Regulation of short-term neuronal synaptic plasticity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STUB1_S19, TGFB1I1_S68, and ACOT7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of short-term neuronal synaptic plasticity activity versus STUB1_S19 in BRCA (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STUB1_S19 →	+0.631	+0.053	<.001	.003	3	6
COAD	TGFB1I1_S68 →	-0.673	-0.033	.001	.002	3	6
GBM	ACOT7 →	+0.362	+0.119	<.001	<.001	3	5
BRCA	THY1 →	-0.553	-0.074	<.001	<.001	3	5
GBM	CNN2 →	-0.694	-0.097	<.001	<.001	3	5
GBM	COPZ2 →	-0.566	-0.107	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048172 vs STUB1_S19 — BRCA

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