Regulation of long-term neuronal synaptic plasticity

Across TCGA cell cohorts, RNA activity of the Regulation of long-term neuronal synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS1, SAMD9, and DUSP14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-term neuronal synaptic plasticity activity versus THBS1 in BONE (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	THBS1 →	+4.901	+0.183	.003	.005	2	6
LARGE_INTESTINE	SAMD9 →	+2.293	+0.363	<.001	<.001	3	5
BONE	DUSP14 →	+1.736	+0.231	<.001	.006	3	5
BLOOD_Myeloma	HILPDA →	-0.746	-0.834	.003	.007	3	5
BONE	NPTN →	+1.058	+0.248	.008	.002	3	4
BONE	SDC4 →	+2.860	+0.240	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048169 vs THBS1 — BONE

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