Regulation of synaptic plasticity

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic plasticity pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECM2, CALU, and TCTEX1D1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic plasticity activity versus ECM2 in OV (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ECM2 →	+2.066	+1.453	.001	.007	3	3
OV	CALU →	+1.174	+1.535	<.001	.004	3	3
OV	TCTEX1D1 →	+0.717	+1.330	.004	.002	3	3
OV	LINC00702 →	+0.580	+1.347	.003	.002	3	3
OV	MAOB →	+1.748	+1.703	<.001	<.001	3	3
BRCA	MEIS3 →	+1.748	+1.516	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048167 vs ECM2 — OV

Explore this scatter interactively →