Fused antrum stage

Across TCGA patient cohorts, RNA activity of the Fused antrum stage pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS6, IER5L, and PPP5D1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fused antrum stage activity versus ADAMTS6 in LSCC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADAMTS6 →	+0.701	+0.192	.001	.005	3	4
GBM	IER5L →	+0.731	+0.149	<.001	.005	3	4
LUAD	PPP5D1 →	-0.232	-0.279	.003	.002	3	3
LUAD	NME1P1 →	+0.976	+0.200	.002	.005	3	3
LSCC	SERPINE1 →	+1.351	+0.465	<.001	.002	3	3
LSCC	LAMA4 →	+0.667	+0.298	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048165 vs ADAMTS6 — LSCC

Explore this scatter interactively →