Fused antrum stage

Across TCGA cell cohorts, RNA activity of the Fused antrum stage pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMPR1B, TNFAIP6, and NPR2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMPR1B grouped by Fused antrum stage-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	BMPR1B →	-0.223	-0.945	.004	.009	3	10
LARGE_INTESTINE	TNFAIP6 →	-0.293	-0.930	<.001	.003	3	9
OVARY	NPR2 →	-0.170	-0.588	.001	.002	3	7
LARGE_INTESTINE	PADI4 →	-0.201	-0.337	<.001	.003	3	4
SKIN	EREG →	-0.188	-0.471	<.001	.005	3	4
BREAST	PTX3 →	-0.286	-0.768	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMPR1B by Fused antrum stage activity — OVARY

Explore this box plot interactively →