Behavioral response to ethanol

Across TCGA patient cohorts, RNA activity of the Behavioral response to ethanol pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKAR, RAPGEF2, and NOSTRIN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Behavioral response to ethanol activity versus ANKAR in CCRCC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANKAR →	+0.280	+0.123	.007	.006	3	5
CCRCC	RAPGEF2 →	+0.460	+0.128	<.001	.003	3	4
CCRCC	NOSTRIN →	+0.898	+0.150	.001	.002	2	5
HNSC	WDSUB1 →	+0.841	+0.174	.001	<.001	3	4
LSCC	NEK3 →	+0.478	+0.595	<.001	.006	3	4
CCRCC	KBTBD7 →	+0.406	+0.137	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048149 vs ANKAR — CCRCC

Explore this scatter interactively →