Behavioral response to cocaine

Across TCGA patient cohorts, RNA activity of the Behavioral response to cocaine pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF3-AS1, PPP1R1B, and DNAJC18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Behavioral response to cocaine activity versus KLF3-AS1 in PDAC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KLF3-AS1 →	+0.282	+0.493	.003	.005	3	4
UCEC	PPP1R1B →	+1.871	+0.799	<.001	<.001	3	4
GBM	DNAJC18 →	+0.349	+0.464	.007	.005	3	4
UCEC	KANK1 →	+0.533	+0.529	.005	.002	3	4
BRCA	DIO3 →	+0.486	+0.284	<.001	.002	3	4
OV	C1orf115 →	+0.731	+0.295	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048148 vs KLF3-AS1 — PDAC

Explore this scatter interactively →