Negative regulation of fibroblast proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of fibroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOMO2, VTI1BP4, and EEF1A1P22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fibroblast proliferation activity versus NOMO2 in CCRCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NOMO2 →	-0.520	-0.539	<.001	.001	3	4
CCRCC	VTI1BP4 →	+0.309	+0.720	.005	<.001	3	3
COAD	EEF1A1P22 →	+0.514	+0.575	<.001	.004	3	3
COAD	UBBP4 →	+0.299	+0.581	.002	.001	3	3
CCRCC	DAB2IP →	+0.711	+0.735	<.001	<.001	3	3
CCRCC	FAM182B →	+0.281	+0.659	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048147 vs NOMO2 — CCRCC

Explore this scatter interactively →