Negative regulation of fibroblast proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of fibroblast proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS6KA5, LILRB2, and RAB39A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS6KA5 grouped by Negative regulation of fibroblast proliferation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RPS6KA5 →	+0.294	+0.299	.001	.002	3	4
OESOPHAGUS	LILRB2 →	-0.244	-0.205	.001	.004	3	4
LUNG_SCLC	RAB39A →	-0.167	-0.224	<.001	.008	3	3
BLOOD_Leukemia	ELF2 →	+0.193	+0.343	.008	.009	3	3
STOMACH	CSF3R →	-0.211	-0.234	.009	.001	3	3
OVARY	PLEK2 →	+0.171	+0.187	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS6KA5 by Negative regulation of fibroblast proliferation activity — BLOOD_Leukemia

Explore this box plot interactively →