Negative regulation of fibroblast proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of fibroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3BP5, NUDT4, and ZNF613, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fibroblast proliferation activity versus SH3BP5 in STOMACH (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SH3BP5 →	-1.805	-0.320	.005	.006	2	6
OESOPHAGUS	NUDT4 →	-1.015	-0.191	<.001	.001	3	4
OESOPHAGUS	ZNF613 →	-1.021	-0.199	.006	.007	3	4
OVARY	ANKRD39 →	+0.816	+0.186	.001	.006	3	4
LUNG_SCLC	NQO2 →	+2.229	+0.261	<.001	<.001	3	4
PANCREAS	GDPGP1 →	-0.677	-0.185	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048147 vs SH3BP5 — STOMACH

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