Regulation of fibroblast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of fibroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRAT2, AXL, and TSPAN12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FRAT2 grouped by Regulation of fibroblast proliferation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FRAT2 →	+2.161	+0.272	<.001	.002	3	5
LARGE_INTESTINE	AXL →	-2.898	-0.241	<.001	<.001	3	5
LIVER	TSPAN12 →	+2.561	+0.310	.001	<.001	3	4
LIVER	PLK2 →	-2.977	-0.209	.003	.003	3	4
LIVER	BEND3 →	+1.065	+0.273	.002	.001	3	4
BREAST	SYCE2 →	-0.809	-0.193	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FRAT2 by Regulation of fibroblast proliferation activity — LIVER

Explore this box plot interactively →