Regulation of fibroblast proliferation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of fibroblast proliferation pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRC and KICH, show the opposite pattern, with lower activity in tumor tissue.

HNSC, KIRC, and KICH show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	All	III,IV	+0.027	<.001	11	view →
KIRC	All	II,III,IV	−0.021	<.001	11	view →
KICH	Female	All	−0.063	<.001	9	view →
LIHC	Female	II,III,IV	+0.043	<.001	8	view →
UCEC	All	III,IV	−0.032	.003	6	view →
BRCA	All	All	−0.029	<.001	6	view →
CHOL	Male	All	+0.088	<.001	5	view →
KIRP	Male	All	−0.029	<.001	4	view →
THCA	All	All	+0.015	.007	4	view →
COAD	Male	II,III,IV	+0.020	.031	2	view →
STAD	Male	II,III,IV	+0.034	.017	1	view →
LUAD	Male	All	+0.018	.044	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0048145–HNSC

Open the HNSC breakdown →