Regulation of fibroblast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of fibroblast proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R12A, MAX, and ZBTB24, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R12A grouped by Regulation of fibroblast proliferation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PPP1R12A →	+0.343	+0.070	.001	.002	3	6
PANCREAS	MAX →	-0.451	-0.125	<.001	<.001	3	5
BREAST	ZBTB24 →	-0.112	-0.080	<.001	.002	3	5
SKIN	HES7 →	-0.285	-0.083	.002	.002	3	5
LUNG_SCLC	NPC1 →	-0.138	-0.091	<.001	.001	3	5
OVARY	C1QA →	+0.258	+0.073	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R12A by Regulation of fibroblast proliferation activity — PANCREAS

Explore this box plot interactively →