Regulation of fibroblast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of fibroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM44, LAMB3, and SLCO3A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fibroblast proliferation activity versus TIMM44 in PANCREAS (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TIMM44 →	-1.057	-0.319	.007	.001	3	7
BREAST	LAMB3 →	+3.633	+0.265	<.001	<.001	3	6
OESOPHAGUS	SLCO3A1 →	+1.090	+0.235	.005	.003	3	6
BONE	ZNF101 →	-0.757	-0.379	.001	.009	2	6
BONE	GPR108 →	+0.611	+0.298	.006	.003	3	5
BONE	DNMT1 →	-1.659	-0.408	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048145 vs TIMM44 — PANCREAS

Explore this scatter interactively →