Fibroblast proliferation

Across TCGA patient cohorts, RNA activity of the Fibroblast proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TJP1_S912, COX7A2, and SOWAHC_S213, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fibroblast proliferation activity versus TJP1_S912 in PDAC (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TJP1_S912 →	-0.868	-0.187	<.001	<.001	3	4
GBM	COX7A2 →	-0.464	-0.219	<.001	<.001	3	4
LUAD	SOWAHC_S213 →	-0.541	-0.125	<.001	<.001	3	3
GBM	WDR37 →	-0.287	-0.156	<.001	<.001	3	3
LUAD	CCAR2_T897 →	+0.872	+0.305	<.001	<.001	3	3
HNSC	CDC42EP3_S100 →	+0.858	+0.254	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048144 vs TJP1_S912 — PDAC

Explore this scatter interactively →