Positive regulation of developmental pigmentation

Across TCGA cell cohorts, RNA activity of the Positive regulation of developmental pigmentation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF319, TOM1, and DNAH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF319 grouped by Positive regulation of developmental pigmentation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF319 →	-1.023	-2.020	.007	.001	3	4
OESOPHAGUS	TOM1 →	-1.478	-1.505	.008	.006	2	4
SOFT_TISSUE	DNAH1 →	-1.147	-1.366	.002	.004	2	4
SOFT_TISSUE	BPTF →	-0.957	-1.944	<.001	<.001	3	3
SOFT_TISSUE	HIC1 →	-1.978	-1.809	.002	<.001	3	3
SOFT_TISSUE	RBM6 →	-0.782	-1.671	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF319 by Positive regulation of developmental pigmentation activity — OESOPHAGUS

Explore this box plot interactively →