Post-embryonic eye morphogenesis

Across TCGA patient cohorts, RNA activity of the Post-embryonic eye morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNC, TAGLN, and FILIP1L, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-embryonic eye morphogenesis activity versus SYNC in UCEC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNC →	+0.565	+0.107	<.001	<.001	3	9
OV	TAGLN →	+1.177	+0.108	<.001	<.001	3	9
UCEC	FILIP1L →	+0.827	+0.137	<.001	<.001	3	9
BRCA	FKBP7 →	+0.601	+0.088	<.001	<.001	3	9
COAD	FMNL3 →	+0.446	+0.096	<.001	<.001	3	9
OV	LGALS1 →	+0.680	+0.091	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048050 vs SYNC — UCEC

Explore this scatter interactively →