Post-embryonic eye morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Post-embryonic eye morphogenesis pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Post-embryonic eye morphogenesis pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and UCS, show the opposite pattern, with higher activity associated with better survival.

BLCA, MESO, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.440	0.576	<.001	101	view →
MESO	OS	Quartile	All	0.216	0.573	<.001	92	view →
KIRP	DFS	Quartile	All	0.733	0.937	<.001	89	view →
STAD	OS	Tertile	All	0.338	0.614	<.001	62	view →
UCEC	OS	Tertile	All	0.882	0.964	<.001	40	view →
LUAD	OS	Quartile	II,III,IV	0.785	0.432	<.001	34	view →
KICH	DFS	Median	All	0.650	1.000	.002	34	view →
COAD	DFS	Quartile	All	0.640	0.831	.004	31	view →
UCS	DFS	Median	III,IV	0.461	0.123	.001	22	view →
OV	OS	Median	All	0.797	0.881	.010	12	view →
THCA	OS	Tertile	II,III,IV	0.957	1.000	.014	12	view →
LUSC	DFS	Quartile	II,III,IV	0.310	0.527	.005	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0048050–BLCA (DFS)

Open the BLCA breakdown →