Post-embryonic eye morphogenesis

Across TCGA patient cohorts, RNA activity of the Post-embryonic eye morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AEBP1, PTPRD, and DNM3OS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-embryonic eye morphogenesis activity versus AEBP1 in OV (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AEBP1 →	+1.670	+0.119	<.001	.009	3	4
LSCC	PTPRD →	+0.839	+0.139	.005	.003	3	4
BRCA	DNM3OS →	+0.854	+0.117	.003	<.001	3	4
COAD	COL10A1 →	+2.068	+0.195	<.001	<.001	3	4
BRCA	OMD →	+0.854	+0.089	.003	<.001	3	4
COAD	SFRP4 →	+2.143	+0.157	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048050 vs AEBP1 — OV

Explore this scatter interactively →