Post-embryonic eye morphogenesis

Across TCGA cell cohorts, RNA activity of the Post-embryonic eye morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF768, LRP8, and MPP7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF768 grouped by Post-embryonic eye morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ZNF768 →	-0.974	-0.264	.009	.006	3	3
SKIN	LRP8 →	+0.775	+1.121	.008	.007	2	4
BREAST	MPP7 →	-1.571	-1.185	.001	<.001	3	3
BREAST	H2AJ →	-1.532	-0.833	.002	.007	3	3
BREAST	NFKB2 →	+0.983	+1.212	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	EMILIN2 →	-1.642	-1.546	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF768 by Post-embryonic eye morphogenesis activity — LIVER

Explore this box plot interactively →