Embryonic eye morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic eye morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, PEAK1, and RSU1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic eye morphogenesis activity versus TLN2 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TLN2 →	+0.508	+0.044	<.001	<.001	3	9
UCEC	PEAK1 →	+0.339	+0.112	<.001	<.001	3	8
UCEC	RSU1 →	+0.577	+0.109	<.001	<.001	3	8
UCEC	KANK2 →	+0.772	+0.087	<.001	.002	3	8
UCEC	FMNL3 →	+0.616	+0.109	<.001	<.001	3	8
OV	ISLR →	+0.740	+0.053	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048048 vs TLN2 — BRCA

Explore this scatter interactively →