Embryonic eye morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic eye morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2N1, MPZL3, and KRT19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAMK2N1 grouped by Embryonic eye morphogenesis-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CAMK2N1 →	-3.317	-2.118	.008	<.001	3	5
OVARY	MPZL3 →	-1.194	-0.888	.003	.001	3	5
OVARY	KRT19 →	-6.389	-1.031	<.001	.006	3	5
BLOOD_Myeloma	MR1 →	-1.124	-1.478	.008	.002	3	4
STOMACH	SMAD9 →	+1.753	+1.238	.004	.007	2	5
URINARY_TRACT	KIAA1522 →	-1.799	-2.039	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAMK2N1 by Embryonic eye morphogenesis activity — URINARY_TRACT

Explore this box plot interactively →