Focal adhesion assembly

Across TCGA patient cohorts, RNA activity of the Focal adhesion assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, PCDHB5, and CALD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Focal adhesion assembly activity versus ACTA2 in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACTA2 →	+2.273	+0.368	<.001	<.001	3	3
BRCA	PCDHB5 →	+0.787	+0.247	<.001	<.001	3	3
BRCA	CALD1 →	+1.581	+0.321	<.001	<.001	3	3
BRCA	TMEM204 →	+0.868	+0.251	.001	.001	3	3
BRCA	ARHGAP20 →	+1.083	+0.320	<.001	<.001	3	3
BRCA	FGF7 →	+1.995	+0.359	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048041 vs ACTA2 — BRCA

Explore this scatter interactively →