"Regulation of mRNA splicing, via spliceosome"

Across TCGA cell cohorts, RNA activity of the "Regulation of mRNA splicing, via spliceosome" pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM25, ACIN1, and CCNT2, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of mRNA splicing, via spliceosome" activity versus RBM25 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RBM25 →	+1.213	+0.104	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	ACIN1 →	+1.016	+0.112	<.001	<.001	3	20
SOFT_TISSUE	CCNT2 →	+1.204	+0.104	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DYNC1LI2 →	+1.102	+0.088	<.001	<.001	3	19
OESOPHAGUS	REV1 →	+1.101	+0.116	<.001	<.001	3	19
KIDNEY	MGA →	+1.447	+0.065	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048024 vs RBM25 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →