Phosphatidylinositol-mediated signaling

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFPQ, GADD45B, and ILF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SFPQ grouped by Phosphatidylinositol-mediated signaling-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SFPQ →	-0.853	-1.601	<.001	<.001	3	5
BLOOD_Lymphoma	GADD45B →	+2.593	+0.268	.004	.008	3	4
CNS	ILF3 →	-0.370	-0.495	.005	.003	3	4
LARGE_INTESTINE	SENP3 →	-0.824	-0.203	<.001	.007	3	4
BONE	TUBB4A →	-2.688	-1.597	.005	<.001	3	4
LIVER	SPAG1 →	+1.385	+0.231	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SFPQ by Phosphatidylinositol-mediated signaling activity — LUNG_SCLC

Explore this box plot interactively →