Ephrin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Ephrin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FSCN1, TIMP2, and TUBA4A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ephrin receptor signaling pathway activity versus FSCN1 in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FSCN1 →	+0.587	+0.036	<.001	<.001	3	6
CCRCC	TIMP2 →	+0.487	+0.048	<.001	<.001	3	6
PDAC	TUBA4A →	+0.330	+0.049	.001	<.001	3	5
UCEC	CAMSAP2 →	+0.369	+0.051	<.001	.004	3	5
PDAC	CYBA →	-0.389	-0.030	.001	<.001	3	5
LSCC	FRMD6_S544 →	+0.870	+0.053	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048013 vs FSCN1 — BRCA

Explore this scatter interactively →