Ephrin receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Ephrin receptor signaling pathway pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 51 member genes.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher Ephrin receptor signaling pathway pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and HNSC, show the opposite pattern, with higher activity associated with better survival.

ESCA, HNSC, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	III,IV	0.788	0.317	<.001	75	view →
HNSC	DFS	Median	II,III,IV	0.734	0.631	.008	57	view →
SCLC	OS	Tertile	II,III,IV	0.756	0.329	.002	46	view →
LGG	OS	Median	All	0.743	0.872	<.001	26	view →
UCEC	DFS	Quartile	All	0.494	0.706	.001	18	view →
PAAD	OS	Tertile	All	0.493	0.646	.015	16	view →
READ	DFS	Tertile	IV	0.402	1.000	.021	12	view →
THCA	DFS	Tertile	III,IV	0.562	0.821	.015	11	view →
SKCM	OS	Tertile	IV	0.856	0.467	.004	9	view →
ACC	OS	Quartile	II,III,IV	0.385	0.871	.007	9	view →
CESC	DFS	Tertile	II,III,IV	0.843	0.652	.025	6	view →
OV	OS	Median	III,IV	0.645	0.710	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0048013–ESCA (OS)

Open the ESCA breakdown →