Ephrin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Ephrin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT6, NUP210, and NDUFC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ephrin receptor signaling pathway activity versus WNT6 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WNT6 →	+0.838	+0.659	.001	<.001	3	4
HNSC	NUP210 →	-0.643	-0.799	.007	<.001	3	4
GBM	NDUFC2 →	+0.513	+0.503	<.001	.001	3	4
GBM	FANCA →	-0.755	-0.544	.003	<.001	3	4
BRCA	MYO3B →	+0.890	+0.516	.004	.005	3	4
OV	FERMT1 →	+0.802	+0.538	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048013 vs WNT6 — BRCA

Explore this scatter interactively →