Ephrin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Ephrin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANK1, PRDM1, and IL13RA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ephrin receptor signaling pathway activity versus FANK1 in PANCREAS (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FANK1 →	-1.161	-0.878	.003	.006	3	4
BLOOD_Lymphoma	PRDM1 →	-2.008	-1.079	.002	.002	2	5
BLOOD_Leukemia	IL13RA1 →	-1.652	-1.175	<.001	<.001	3	4
BLOOD_Leukemia	CD63 →	-1.085	-1.314	.003	<.001	3	4
BLOOD_Leukemia	RB1 →	+0.734	+0.699	.006	.006	2	5
BLOOD_Leukemia	PELP1 →	+0.522	+1.005	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048013 vs FANK1 — PANCREAS

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