Ephrin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Ephrin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MRPS36, EPHA2, and PSMB5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ephrin receptor signaling pathway activity versus MRPS36 in PANCREAS (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MRPS36 →	-0.791	-1.113	.009	.001	3	9
BREAST	EPHA2 →	+1.561	+1.057	.008	.008	3	6
CNS	PSMB5 →	+0.828	+0.922	.002	.009	2	7
BLOOD_Myeloma	PTPN11 →	+0.644	+1.379	.006	.009	2	7
PANCREAS	KPNA2 →	+2.037	+1.195	<.001	<.001	3	6
PANCREAS	FH →	-0.652	-0.954	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048013 vs MRPS36 — PANCREAS

Explore this scatter interactively →