Hepatocyte growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Hepatocyte growth factor receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSO, SQOR, and NCKAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTSO grouped by Hepatocyte growth factor receptor signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CTSO →	+0.228	+0.233	.003	<.001	3	6
OVARY	SQOR →	-0.179	-0.115	.002	.001	3	5
LARGE_INTESTINE	NCKAP1 →	+0.343	+0.160	<.001	<.001	3	5
PANCREAS	PSMD4 →	+0.370	+0.234	<.001	<.001	3	5
BLOOD_Leukemia	KPNA1 →	+0.359	+0.170	<.001	<.001	3	5
BONE	PCDHA11 →	-0.245	-0.281	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTSO by Hepatocyte growth factor receptor signaling pathway activity — BLOOD_Myeloma

Explore this box plot interactively →