Neurotrophin TRK receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Neurotrophin TRK receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOS1, USP34, and ZDHHC17, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotrophin TRK receptor signaling pathway activity versus SOS1 in CHOL (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	SOS1 →	+1.009	+0.088	<.001	<.001	3	33
DLBC	USP34 →	+2.103	+0.040	<.001	.002	3	32
UVM	ZDHHC17 →	+1.254	+0.045	<.001	<.001	3	32
CHOL	KANSL1 →	+0.803	+0.083	<.001	<.001	2	32
THYM	SBF2 →	+1.372	+0.084	<.001	<.001	3	31
CHOL	KIDINS220 →	+1.593	+0.102	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048011 vs SOS1 — CHOL

Explore this scatter interactively →