Neurotrophin TRK receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Neurotrophin TRK receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAM1, QSOX1, and PLK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAM1 grouped by Neurotrophin TRK receptor signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TRAM1 →	+1.334	+1.150	.001	.001	3	5
OESOPHAGUS	QSOX1 →	+1.596	+1.569	<.001	<.001	3	5
LUNG_NSCLC_LUSC	PLK2 →	+2.472	+0.990	.005	.005	3	5
OVARY	GPRC5A →	+2.738	+1.634	.005	<.001	2	5
OESOPHAGUS	CST6 →	+4.633	+1.402	.005	<.001	3	4
OVARY	LACC1 →	+0.786	+1.077	.002	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAM1 by Neurotrophin TRK receptor signaling pathway activity — LIVER

Explore this box plot interactively →