Neurotrophin TRK receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Neurotrophin TRK receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEN1, MAL2, and P3H1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotrophin TRK receptor signaling pathway activity versus MEN1 in PANCREAS (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MEN1 →	+0.804	+1.295	<.001	.002	3	4
URINARY_TRACT	MAL2 →	-6.063	-1.898	<.001	<.001	3	4
OVARY	P3H1 →	+1.631	+1.570	.005	<.001	3	4
SKIN	KLHL3 →	-0.477	-1.278	.007	.004	2	5
SKIN	INKA1 →	+0.897	+1.451	.004	<.001	3	4
LUNG_SCLC	PHLDB2 →	-2.598	-1.272	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048011 vs MEN1 — PANCREAS

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