Neurotrophin TRK receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Neurotrophin TRK receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASP3, AKT1S1, and SGTA, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotrophin TRK receptor signaling pathway activity versus CASP3 in SOFT_TISSUE (Pearson r = 0.86).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CASP3 →	+1.304	+1.948	<.001	<.001	3	14
OESOPHAGUS	AKT1S1 →	+1.533	+1.544	.001	<.001	3	12
SOFT_TISSUE	SGTA →	+1.589	+1.343	.002	.001	3	12
SKIN	RPS20 →	+0.651	+1.133	.002	.001	3	12
URINARY_TRACT	NUTF2 →	+1.640	+1.878	.004	<.001	3	11
SOFT_TISSUE	RPS12 →	+1.357	+1.443	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048011 vs CASP3 — SOFT_TISSUE

Explore this scatter interactively →