Vascular endothelial growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Vascular endothelial growth factor receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VWA1, COL4A1, and LAMC1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular endothelial growth factor receptor signaling pathway activity versus VWA1 in CCRCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VWA1 →	+0.590	+0.074	<.001	<.001	3	10
OV	COL4A1 →	+0.545	+0.046	.002	.001	3	10
COAD	LAMC1 →	+0.547	+0.040	<.001	<.001	3	10
CCRCC	SMTN →	+0.732	+0.085	<.001	<.001	3	9
BRCA	SSC5D →	+0.666	+0.030	<.001	<.001	3	9
COAD	ACTN1 →	+0.544	+0.034	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048010 vs VWA1 — CCRCC

Explore this scatter interactively →