Vascular endothelial growth factor receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Vascular endothelial growth factor receptor signaling pathway pathway differs between tumor and matched normal tissue in 14 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUSC and KICH, show the opposite pattern, with lower activity in tumor tissue.

HNSC, KIRC, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	Female	IV	+0.106	<.001	11	view →
KIRC	Female	All	+0.050	<.001	9	view →
LUSC	Female	All	−0.059	<.001	8	view →
KICH	Male	II,III,IV	−0.043	<.001	8	view →
KIRP	Male	All	−0.060	<.001	7	view →
BRCA	All	III,IV	−0.068	<.001	6	view →
LUAD	Female	All	−0.033	<.001	6	view →
LIHC	All	All	+0.019	.001	3	view →
UCEC	All	All	−0.045	.002	2	view →
BLCA	All	All	−0.027	.042	2	view →
READ	Female	All	−0.058	.028	1	view →
THCA	All	IV	−0.052	.043	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 14 lineages.

GO:0048010–HNSC

Open the HNSC breakdown →