Vascular endothelial growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Vascular endothelial growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAG1, VEGFB, and SMU1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAG1 grouped by Vascular endothelial growth factor receptor signaling pathway-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RAG1 →	+1.540	+0.399	.005	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	VEGFB →	+1.066	+0.285	<.001	<.001	3	4
SKIN	SMU1 →	+0.602	+0.958	.001	.005	3	3
SKIN	VGF →	-3.245	-0.982	.009	.004	3	3
URINARY_TRACT	ASXL1 →	+0.758	+0.386	.009	.001	3	3
OESOPHAGUS	TM9SF1 →	-0.975	-0.235	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAG1 by Vascular endothelial growth factor receptor signaling pathway activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →