Vascular endothelial growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Vascular endothelial growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD2, MAP7D3, and KLF16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular endothelial growth factor receptor signaling pathway activity versus FZD2 in BLOOD_Leukemia (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FZD2 →	+0.760	+0.189	.004	.009	3	4
OVARY	MAP7D3 →	+0.903	+0.654	.006	.003	3	4
OVARY	KLF16 →	+0.813	+0.817	<.001	.008	3	4
SOFT_TISSUE	PPP2CA →	+0.887	+0.275	.001	.003	3	4
KIDNEY	NCK1 →	+0.765	+0.336	.005	<.001	3	4
SOFT_TISSUE	C16orf74 →	+2.360	+0.347	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048010 vs FZD2 — BLOOD_Leukemia

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